Why are betaine, papain, and bromelain not very effective in digestion?

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Why are betaine, papain, and bromelain not very effective in digestion?

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Betaine is not a enzyme. During the digestive process, betaine donates methionine (which contains sulfur) to the liver for the assimilation of protein. Papain and bromelain are plant enzymes that have their peak activity temperatures above body temperature. At body temperature, bromelain and papain work at reduced efficacy. The plant enzymes in the enzyme supplements that I use have their peak activity range between 95 and 105 degrees Fahrenheit, well within body temperature.

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