Why are clopidogrel and Proton Pump Inhibitors in the news?
Several studies have recently shown that clopidogrel is less effective in preventing the recurrence of unstable angina, heart attack and stroke in patients who are also taking a PPI. This issue has recently been considered by the European Committee for Medicinal Products for Human Use (CHMP), and they have recommended that information for prescribers and patients is updated. 5. What is the new advice? CHMP has advised that patients who are taking clopidogrel should not take a PPI at the same time unless it is absolutely necessary. 6. Does the new advice apply to all PPIs? Yes, including omeprazole that you can buy over-the-counter. Although the strength of the evidence for an interaction between clopidogrel and PPIs varies for each member of the class, studies that have evaluated the effect of taking clopidogrel and PPIs on the rate of heart attack or stroke suggest that the interaction may occur with all members of the class. 7. What should I do if I am taking clopidogrel and a PPI? T
