Why buy a pKD siRNA plasmid instead of a synthetic siRNA?
The pKD plasmids are offered as an option for those customers looking for different siRNA alternatives. There are three advantages that the pKD family of products offers over synthetic siRNA. 1.) If more is needed, more can be made by the purchaser with a quick and simple plasmid prep instead of having to purchase the product again. 2.) The length of the siRNA-mediated knock-down can be longer due to the fact that any siRNA that gets degraded by the cell will be replaced by more siRNA due to its continuous transcription off of the plasmid. With synthetic siRNA, when the cell degrades it, there is nothing there to replace it except a second transfection. 3.) The pKD mammalian siRNA expression plasmids can be stably integrated into the cellular genome.
