Why did the researchers study FHM?
Previous research has shown that FHM mutations affect the function of calcium channels. The new study investigated the cellular effects of several mutations linked to FHM. The researchers looked at structures located in cell membranes called calcium channels, which allow calcium ions to enter cells. What affect did the mutations have on migraine? The researchers found that all of the mutations increased the flow of calcium ions into cells. At the same time, the maximum electrical current in calcium channels was decreased in cells that expressed FHM mutations. These changes in calcium channels most likely lead to an increased release of excitatory chemicals in the brain, making the brain overly excitable and favoring the slowly spreading abnormal electrical activity that causes the migraine aura and headache. Are there any processes that might help researchers understand migraine? Some people experience a visual aura, beginning at some point before the migraine, typically 20 to 40 minut