Why Do Dripping Pills Increase Bioavailability?
Formation of tiny, fine crystals: In the preparation of dripping pills, herbal extract and matrix are melted together to make a solution in which the herbal extract is distributed in molecular form within the matrix. When the solution cools down the solubility decreases and the molecules of the herbal extract are separated out. Due to rapid cooling, the viscosity of the solution increases rapidly, the solution is solidified, and the botanical molecules separated out cannot conglomerate into large crystals. As a result, micro-crystals are formed. These micro-crystals have a rapidly-dissolvable property within body fluids and a better bioavailability. For example, when Griseofulvin (an antifungal drug) Dripping Pill with PEG 6000 in its matrix is examined under a microscope, it can be seen that crystals at a size between 2-3 micrometer account for only 5.39%, while the remaining is composed of crystals under 2 micrometer. Dissolubility, solubility and surface activity of the matrix In dr
