Why do some cells have multiple nuclei?
Nearly all our cells started out with just one nucleus, including skeletal muscle There are only some specific cells that start out with a single nucleus and when they mature end up with either more than one nucleus (e.g. skeletal muscle, heart cells, osteoclasts) or others without a nucleus (e.g. red blood cells) For example, skeletal muscles start out in development as a large number of single nuclei cells (myoblatsts) that when they differentiate (mature) fuse together to form a single muscle cell/muscle fibre which may have 100’s of nuclei form the original cells For example, red blood cells start out with a nucleus in the bone marrow and when they differentiate (mature) within the marrow they expel their nucleus.
