Why do the acceptance criteria use the geometric mean rather than arithmetic?
Experience with this lot of Prednisone Tablets RS and prior PVT collaborative studies has shown that the data are better analyzed in the log scale to improve the normality assumption. The acceptance limits are actually for the arithmetic mean and standard deviation in the log scale. The limits are converted back to the percent dissolved scale to make them more interpretable. This conversion changes the arithmetic mean and standard deviation into a geometric mean and %CV. See the 2008 Stimuli Article (527KB) for details.
