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Why does dilantin have a smaller retention time in reversed phase HPLC as compared to benzil?

April 26, 2017benzil dilantin hplc phase retention reversed smaller time

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Why does dilantin have a smaller retention time in reversed phase HPLC as compared to benzil?

1 Answer

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My guess is that it is because Dilantin has two benzyl substituents on one carbon, adding steric hindrance. Second, the ring is very electron deficient, and so unstable. Benzil has less steric hindrance and is linear.