Why is GOLD unable to dock a particular ligand?
The vast majority of problems of this nature are caused by incorrectly set up ligand and/or protein input files. GOLD uses an all atom model, so the protein and ligand must have all hydrogens added. In addition, each ligand and protein atom must be assigned an atom type. GOLD atom typing is based on SYBYL atom types, SYBYL bond types are also used. The correct assignment of atom and bond types is crucial for GOLD to function correctly. For further information about setting up your protein and/or ligand please refer to the GOLD online documentation.
