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Why is Jeremy heavier in some Holmes episodes?

heavier Holmes Jeremy
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Why is Jeremy heavier in some Holmes episodes?

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Apparently, the medication prescribed to control Jeremy’s bipolar disorder built up in his system over time and wreaked havoc on his heart, causing him to retain water. This explains his bloated appearance in many later episodes. When Jeremy’s heart began to fail, his medication was adjusted. Heart medicine and diuretics were prescribed, and his weight returned to nearly normal (unlike his health, unfortunately).

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