Why must Ventavis be administered with the I-neb AAD System?
A. Although there are many aerosol devices approved in the U.S., it is important that Ventavis be dosed only via the I-neb AAD System. Only the I-neb AAD System is currently available and has been FDA approved to deliver safe and accurate dosing of Ventavis. Standard airjet nebulizers/compressors or ultrasonic nebulizer systems, such as those used to deliver inhalation solutions for asthma, are continuous flow systems that constantly generate aerosol. Patients typically have a 40:60 inhalation:exhalation ratio; therefore, about 60% of the drug is wasted to the environment with such devices during exhalation. Additionally, a variable amount of drug is inhaled by each patient because individual breathing patterns differ (e.g., short, shallow breaths to long, deep breaths). In contrast, Ventavis is a potent prostacyclin analogue which requires precise, reproducible dosing of Ventavis to every patient for the safety and efficacy of the drug. The I-neb AAD System only delivers the drug duri
