Why sequence multiple species and strains?
A wide variety of microbial sequencing projects having been completed or being implemented throughout the world has created a rich and diverse ‘mega-database’ of microbial genomes. However, to fully gauge the prevailing diversity and stratification patterns of all bacterial species, it will be required to sequence hundreds and thousands of genomes representing all branches and lineages within the bacterial and archaeal part of the tree of life wherein each of the phylum provides an opportunity to capture evolutionary footprints of billions of years. It is estimated that there are at least 35 different phyla of bacteria according to the rRNA gene sequence based tree of life [12]. The genome sequences of bacteria that have accumulated so far represent only three phyla, thus leaving major gaps in the genomic representation of the bacterial diversity of our biosphere. It is therefore urgently required to sequence genomes from underrepresented phyla and to improve resolution of deep branche
Related Questions
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