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Why would I choose a whole molecule FAB specific, or Fc specific, or light chain specific antibody?

April 26, 2017Antibody chain FAB FC light molecule

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Why would I choose a whole molecule FAB specific, or Fc specific, or light chain specific antibody?

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• Polyvalent antibodies react with all classes. Fc and heavy-chain specific antibodies only react with heavy chains and are, therefore, class specific (i.e. gamma chain specific reacts only with IgG; µ chain specific reacts only with IgM, etc.) Fab and whole molecule (wm) specific antibodies react with heavy and light chains. Due to the light chain reactivity, they can react with all classes. Light chain (kappa, lambda) specific antibodies react with all classes, since all classes use the same kappa or lambda light chains.