Will use of a spermicide alone reduce the risk of HIV infection?
The extent to which spermicides alone may provide protection has not been well documented. Spermicides applied within the vagina may provide some protection against the virus contained in semen, but they should not be used without a condom or diaphragm. Frequent spermicide use, for example more than every other day, is not advised because it can cause irritation, which may increase the risk of infection. WARNING: This method of protection should only be used if there are no other choices possible, as the very last resort.