Would I do better switching to Sinemet CR?
” Mrs. Star’s response to carbidopa/levodopa is a bit erratic and doesn’t last long (2 hours). With the sustained-release form, she could increase the interval between doses to three hours, but he should anticipate an even more erratic effect. She may do better sticking with the immediate-release formulation. Mr.Teller: “I’m taking two 25-100 immediate-release carbidopa/levodopa tablets every four hours. I would like to switch to the sustained-release drug so that I wouldn’t have to take it as often.” There are rules for making this switch, allowing us to come up with a dose that is approximately equivalent in potency to what he is taking now. Subsequently further dose adjustment can be done to better fine-tune the response. First, we will derive the comparable dose of the sustained-release formulation. The individual sustained-release doses need to be 30-50 percent greater, compared to the immediate-release form. Currently Mr. Teller takes two 25-100 tablets, providing 200 mg levodopa