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Tissue plasminogen activator (t-PA) is produced endogenously by endothelial cells. It works by converting proenzyme plasminogen to activated enzyme plasmin. Activated plasmin in turn dissolves fibrin clots into LMW fibrin degradation products. It
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For a number of years, t-PA (Activase® Alteplase) has been used in the treatment of acute myocardial infarction. The U.S. Food and Drug Administration (FDA) has approved the use of t-PA to reestablish blood supply to tissue damaged in an acute
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Yes. However, it is recommended that the stroke team physician approve the clinical protocols or pathways. -Top- • What data tool or format do you need to use for measuring stroke care and performance? You can use any tool, providing you collect the
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The performance measurement has a primary rate and a secondary rate. The primary rate consists of all patients with acute ischemic stroke whose time from symptom onset to arrival in the emergency department is less than three hours and who were
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No. The performance measure is specific to IV t-PA. -Top- • How does the organization evaluate the patients’ perception of care and program effectiveness? Patient satisfaction tools and phone surveys are methods use to evaluate patient perception of
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Urgent treatment of an acute stroke with t-PA, a clot-dissolving medication, has the potential to completely prevent the permanent brain damage that a stroke might otherwise cause. Unfortunately, it also has the potential to cause serious, even
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