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Are diet-prostate cancer associations mediated by the IGF axis?

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Are diet-prostate cancer associations mediated by the IGF axis?

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Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, UK. D.J.Gunnel@bristol.ac.uk We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.

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