Are the scenarios addressed representative and comprehensive, considering the public health risk evaluated?
Reviewer #1. The three scenarios are quite useful but may not be completely representative or comprehensive. There may actually be worse case scenarios that should be considered in addressing potential public health risk. There might be a greater additive effect if multiple sources of exposure are considered. Another factor that should be considered is human consumption of pet food which does occur in some human populations. The final issue is the need to consider possible background exposures to melamine and its analogues likely through plastic products. One scenario should also focus on a longer duration of exposures and the potential outcome of chronicity. Reviewer #2. See response to Question 8. Reviewer #3. The three scenarios are appropriate and cover the scope of risk categories. They are at the macro-level and define the gross risk of consumption. The scenarios appear to assume no bioaccumulation over time (This is of course adjusted some by the calculation for Tolerable Daily