A. Greek philosopher and physician Galen suggested that “melancholy” women are more susceptible to breast cancer. Psychologists have assessed certain groups of cancer patients, where they claim that psychological factors have a bearing on the development of cancer. The basic cause of cancer is the defective immune system, its failure to detect and eliminate the abnormal cells. The immune system does not work on its own, in isolation. It can be influenced by the central nervous system and the endocrine system (responsible for the hormonal secretions). If the person is psychologically affected, it affects the hormonal status of the body also and hence the immune system becomes functionally depressed. For example, bowel cancer affects many people suffering from Ulcerative colitis later. The probable reason here may be the psychological factors because Ulcerative colitis itself leads to psychological depression. Hence, we can say that though psychological factors may not directly cause can