There have been no reported adverse side effects. The Hoodia Gordonii used to make Phentraslim Plus™ is all natural and contains no harmful stimulants or ephedrine. Phentraslim Plus™ contains no yeast, wheat, soy, starch, sugar, salt, dairy, artificial flavors, colors or animal products. However, if you are experiencing any physical or health concerns, it is always best to consult with your physician.