How are these new results different from the information that was released in July 2002?
There are two studies in the WHI Hormone Program. These new findings come from the Estrogen-Alone (E-Alone) study. Findings from the Estrogen-Plus-Progestin (E+P) study were released in July 2002. There are many differences between these two studies: • Women who joined the WHI Hormone Program were enrolled in the E-Alone or E+P study depending on whether or not they had a hysterectomy before joining. We did this because, when health care providers prescribe hormones to women with a uterus, progestin is usually added to estrogen to protect against endometrial (uterine) cancer. Therefore, the hormone pills used in the two studies were different. • Women in the two studies had different health characteristics when they joined the WHI Hormone Program, even before they started taking study pills. For example, women in the E-Alone trial were at higher risk for a heart attack and stroke, because they had higher blood pressure and weighed more than women in the E+P trial. More women in the E-A
