In the most severe cases of kidney stones – patients that need surgical intervention to remove the stones – taking the systemic enzymes made them significantly less likely to get stones again. Now what is interesting is that in those studies, the patients took enzymes for only four to five weeks – but they still had less risk of developing new kidney stones a year later!! From what I have been able to find in the literature, I would say that by decreasing inflammation (and decreasing pro-inflammatory cytokines such as IL-6 – which is associated with kidney stone formation) , and pro-Wobenzym is able to inhibit the development of kidney stones decrease the inflammatory. But more than that, the enzymes in Wobenzym have proteolytic properties may decrease formation of the organic (protein) component of the kidney stone. In addition, the enzymes appear to be interacting with bikunin, a glycoprotein that is a member of the inter-alpha-trypsin inhibitor (ITI) family. Like alpha-2-macroglobul