How does Genmab create human monoclonal antibodies?
Genmab uses groundbreaking technology that can create human antibodies which our own immune system does not make, antibodies that are specific for a disease target. We can then reproduce those antibodies in large quantities as needed. These special antibodies are called monoclonals. A monoclonal antibody is a type of antibody produced in the laboratory from a single cell known as a hybridoma. Early monoclonal antibody technology has been based on the use of laboratory mice to create antibodies. These mouse antibodies are then engineered to reduce the amount of mouse proteins through a process that requires substantial time, money and effort. Ultimately, the resulting “chimeric” or “humanized” antibodies still contain some mouse proteins and can potentially be rejected by a patient’s immune system. Nevertheless, these part-mouse and part-human monoclonal antibodies have shown some success. Genmab has the ability to produce antibodies that are 100 percent human. In the high tech mice use
