How does Thrombin-JMI® compare with human thrombin or recombinant human thrombin?
Based on the efficacy data available to date, Thrombin-JMI® was shown to be equally effective as either hThrombin or rhThrombin. No significant differences in overall clinical adverse events or serious adverse events were observed in head-to-head clinical trials with either the human or the recombinant topical thrombin product vs Thrombin-JMI®. To date, the available clinical data for hThrombin vs Thrombin-JMI® and for rhThrombin vs Thrombin-JMI® have failed to demonstrate a difference in efficacy or clinical adverse events despite a difference in antibody formation.4,5 A significantly greater proportion of patients who received Thrombin-JMI® was reported to have experienced seroconversion.4,17 During the past 14 years, Thrombin-JMI® has been used in an estimated 14 million patient procedures.1,29 In addition, Thrombin-JMI® offers multiple delivery options so that surgeons can apply Thrombin-JMI® in a way that best suits the bleeding site-ranging from coverage of large surface areas to
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