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How to take T3?

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A. Unlike T4, T3 is very fast acting. It can be slowed down by mixing it with a slow release substance. This is not commercially available but may be obtained from a compounding pharmacy (not a regular pharmacy). Because even the slow release T3 has a peak action of only a few hours, it is best to take it in divided doses. Thus a 15 mcg daily dose can be taken as 7.5 mcg approximately every 12 hrs. Or better yet, 5 mcg approximately every 8 hrs. The adrenals are less stressed if their metabolic environment is stable. According to pharmacological principles, a dose of medication will produce blood level of the medication that rises and then falls. If taken as 2 separate doses, the blood level is more stable. 3 doses produce an even more stable blood level, etc. Cytomel is an example of a fast acting T3. It produces a strong immediate effect (high blood level) which is followed by a weak effect (low blood level). It may require breaking up the dose into many small doses. Note that a ... more
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