Is macular degeneration hereditary?
Macular degeneration appears to be hereditary in some families but not in others. Since macular degeneration affects most patients later in life, it is difficult to study successive generations in a family. Recent studies of twins indicate that both genetic and non-genetic factors play important roles in age-related macular degeneration. Research is underway to determine the genes associated with hereditary macular degeneration which may help lead to early detection, early intervention, and possible cures. Heredity plays a major factor in one’s ability to fight free radicals in various parts of the body, which play a part in the development of macular degeneration. Fortunately, dietary and lifestyle changes can sometimes overcome poor heredity in many of these cases.
Age-related macular degeneration (AMD) usually affects individuals older than 50 years of age, and scientific evidence shows that genes may play a role in the development of nearly three out of four cases of this devastating eye disease. While there is definitely a strong genetic component to AMD, it is highly likely that development of AMD is due to a combination of multiple factors including hereditary gene mutations or variations as well as environmental factors such as sunlight exposure, diet, and smoking.
Macular degeneration appears to be hereditary in some cases. Since macular degeneration affects most patients later in life, it is difficult to study successive generations in a family. Recent studies of twins indicate that both genetic and non-genetic factors play important roles in age-related macular degeneration. Genetic variants in at least two genes have been discovered which increase susceptibility by 2.6-4.5X.
Related Questions
- Do you or someone you know have low vision caused by Macular Degeneration, Retinitis Pigmentosa (RP), Diabetes, or another vision condition?
- What is photodynamic therapy, when is it used to treat age-related macular degeneration (AMD) and what are the risks/benefits?
- What is age related macular degeneration (ARMD)?
