Is Prednisone any different than Medrol on the ACTH suppression on the Pituitary, given the equivalent doses, i.e. 6mg of medrol and 7.5mg of prednisone, or 30mg of hydrocortisone?
Medrol is the trade name for methyl prednisolone, it is a little more potent than prednisolone, but at appropriate doses, all three steroids have about the same pituitary suppression. Cortisol is a little shorter acting, so depending how frequently it is given, it may have slightly less suppression of the pituitary. Prednisone and methyl prednisolone are frequently used to treat inflammatory problems such as colitis or some kidney problems because they cause less salt retention and have more potent as anti inflammatory activity than cortisol. They tend to be used in larger doses in these situations and therefore can cause greater pituitary suppression. I was diagnosed with Addison’s disease in 1992. I have always been told that I shouldn’t take anti-inflammatory medication, can you tell me why? I am currently suffering from muscle spasms. I have been prescribed Baclofen vs. an anti-inflammatory. Anti inflammatory medications can cause stomach irritation and ulcers. These are the major
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