What are some features that differentiate Parkinson-like syndromes from PD?
Features that differentiate Parkinson-like syndromes from PD include: lack of a clinical response to levodopa or a dopamine agonist; lack of asymmetric motor signs; rapid decline over several months to one year; and presence of clinically significant dementia early in the course of predating motor signs. • What disease characteristics may be used to distinguish PD, drug-induced Parkinsonism, and other Parkinson-like syndromes? Disease characteristics that may be used to distinguish between Parkinson’s disease, drug-induced parkinsonism, and other Parkinson-like syndromes include: asymmetric vs. symmetric motor signs; time frame of progression; and response to pharmacologic therapy. • When should a speech therapy evaluation be considered for a patient with Parkinson’s disease? Consider a speech therapy evaluation if there is a significant change in the patient’s cognition or ability to communicate. • What are common side effects of the drug levodopa? Side effects of levodopa include the