What is a late phase or bi-phasic anaphylactic reaction?
A late phase reaction is a second reaction that occurs between approximately 4 to 8 hours after the initial reaction. Late phase reactions can be in the form of rhinitis, asthma, hives, and even anaphylaxis. Generally, one must have an immediate reaction to set up a late phase reaction but this is not always the case. The immediate reaction releases chemical mediators in the body that then recruit more cells that release more chemicals that causes a continuation of the reaction. In patients who have anaphylaxis, there is about a 60% chance of a late phase reaction, which is why observation in an emergency room is essential. A late phase reaction may even be more severe than the immediate response.These questions were answered by: Marc S.
A late phase reaction is a second reaction that occurs between approximately 4 to 8 hours after the initial reaction. Late phase reactions can be in the form of rhinitis, asthma, hives, and even anaphylaxis. Generally, one must have an immediate reaction to set up a late phase reaction but this is not always the case. The immediate reaction releases chemical mediators in the body that then recruit more cells that release more chemicals that causes a continuation of the reaction. In patients who have anaphylaxis, there is about a 60% chance of a late phase reaction, which is why observation in an emergency room is essential. A late phase reaction may even be more severe than the immediate response. These questions were answered by: Marc S.
