What Is IUI Treatment? IUI, or intrauterine insemination, is a relatively simple infertility treatment, where a small tube is used to place specially washed sperm directly into the uterus. You may know of IUI by the more commonly used term artificial insemination (AI). IUI and AI are one and the same fertility treatment. When considering fertility treatments above and beyond fertility drug use, IUI may be the first tried. It’s easier to do than assisted reproductive technologies, like IVF, and costs much less. According to a survey done by RESOLVE, the average IUI fertility treatment costs $895 (compared to $8,000 to $15,000 for IVF). When Is IUI Treatment Used? IUI may be used in some cases of male factor infertility, like low sperm counts or if a sperm donor is being used. IUI may also be used if the woman’s cervical mucus is less than i