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What is linkage disequilibrium (LD)?

April 26, 2017Disequilibrium LD Linkage

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What is linkage disequilibrium (LD)?

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LD refers to non-random statistical associations between unlinked alleles in individuals randomly sampled from a population. Alleles in LD are co-inherited more often than would be expected by chance alone. Such allelic associations arise because of non-random mating among individuals. When specific, unlinked alleles in the genome are known to be in LD, this indicates that the ancestries of the genes that are physically linked to those alleles (haplotypes) will also tend to be correlated.