What was the hormone used in the Estrogen-Alone study?
Women in the Estrogen-Alone study were randomized to take either a placebo pill or an active pill containing 0.625 mg of conjugated equine estrogens (CEE, commonly known as Premarin®) each day.The CEE was taken alone, without the addition of a progestin. Estrogen-Alone participants had a hysterectomy before joining the WHI, so they did not need to worry about estrogen effects on endometrial (uterine) cancer. Women in the Estrogen-Plus-Progestin study were randomized to take either a placebo pill or this same hormone, CEE, plus 2.5 mg medroxyprogesterone acetate (CEE+MPA; commonly known as Prempro®) each day.Because participants in this other Hormone Program study still had a uterus, a progestin (MPA) was added to the CEE to protect against endometrial (uterine) cancer.
