Who gets Metachromatic Leukodystrophy?
How serious is Metachromatic Leukodystrophy? Prognosis of Metachromatic Leukodystrophy: Poor. Life-shortening. Often death 3-6 years after onset for infantile form; death within 6-14 years of onset for other forms. Prognosis of Metachromatic Leukodystrophy: The prognosis for MLD is poor. Death generally occurs within 6 to 14 years after onset of symptoms. In the infantile form death may occur between 3 and 6 years after onset.