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Can a dose of 2microg.kg(-1) caudal clonidine cause respiratory depression in neonates?

April 26, 2017caudal cause clonidine depression dose neonates PubMed respiratory

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Can a dose of 2microg.kg(-1) caudal clonidine cause respiratory depression in neonates?

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A case of multiple life-threatening postoperative apnoeas in a term neonate undergoing inguinal herniorrhaphy and orchidopexy who received light inhalation anaesthesia combined with caudal block with 1 ml.kg-1 ropivacaine 0.2% plus 2 microg.kg-1 clonidine is reported. The patient showed no apparent risk factors for postanaesthetic apnoea. Oxycardiorespirography five days after surgery only showed minor abnormalities. Clonidine though administered caudally in the usual dose of 2 microg.kg-1 appeared to be the most likely cause for postanaesthetic apnoea in this neonate.