What is Platelet Function Defect (PFD)?
There are several types of platelet function defects. There are also different degrees of severity. Sometimes, the number of platelets is normal but, the platelets do not work as they should. Bernard-Soulier Syndrome is a rare hereditary PFD. In this syndrome platelets cannot stick and spread to sites of blood vessel damage. Glanzmann’s thrombasthenia is also a rare hereditary PFD. In this case platelets are unable to group and form clumps. Most PFDs found are of the mild hereditary type. These PFDs do not “go away”. Patients who have the hereditary type of PFD will have it for the rest of their lives. There are also outside causes of PFDs. These include PFDs caused by certain medical conditions. Or, they may be caused by the use of medicines that affect platelet function such as: • aspirin • non-steroidal anti-inflammatory drugs (such as ibuprofen and naproxen) • blood thinners, • some antibiotics, • antidepressants • anesthetics • heart drugs. Platelet function returns to normal when
