Are there factors that can cause false eGFR results?
• Children under the age of 18 years (alternative calculation required) • Racial groups (not yet defined) • Rapidly changing renal function • Rapidly changing body fluid distribution • Pregnancy • eGFR < 30 mL/min Increase in serum creatinine (decreased eGFR) • Kidney disease (reduced glomerular function) • Reduce renal perfusion • Large muscle mass (do not confuse with fat) • Abnormally rapid muscle breakdown • High protein intake (cooked meat may transiently increase creatinine production; there may be a transient increase in actual GFR) • Marked extra-cellular fluid decrease • Very poor glucose control • Drugs causing increased creatinine release from muscle (active vitamin D metabolites, corticosteroids, fenofibrate) • Drugs causing decreased proximal tubular secretion of creatinine (cimetidine, phenyl acetamide, pyrimethamine, salicylates, trimethoprim • Drugs having an effect that is not understood (nonsteroidal anti-inflammatories, pyrimethamine)
