Can Angiogenesis Inhibitors Help Control Malignant Growth?
A primordial event in the young fetus is vasculogenesis: the transformation of progenitor cells into interconnecting tubes of endothelial cells that act as conduits for the circulating blood, enabling it to perfuse all body tissues. Starting nearly at the same time, new capillaries sprout from existing vessels in what is aptly called angiogenesis, which literally means the “birth of vessels.” These new vessels eventually are pruned and remodeled, developing into the adult circulatory system. Endothelial cells are ordinarily quiescent-their turnover time is measured in years-unless activated by a situation that increases the body’s need for blood, such as the menstrual cycle, a healing wound, and certain ocular diseases. Another situation, which has attracted much interest in recent years, is the formation and growth of tumors. The field of angiogenesis research, an exotic concept to most physicians a quarter century ago, now commands two journals devoted exclusively to answering such q
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- Can Angiogenesis Inhibitors Help Control Malignant Growth?
