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Can changes of ryanodine receptor expression affect cardiac contractility?

April 26, 2017affect cardiac changes contractility expression receptor

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Can changes of ryanodine receptor expression affect cardiac contractility?

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Treatment of heart failure through stabilization of the cardiac ryanodine receptor. [Circulation. 2003] Treatment of heart failure through stabilization of the cardiac ryanodine receptor.Hasenfuss G, Seidler T. Circulation. 2003 Jan 28; 107(3):378-80. Gain and cardiac E-C coupling: revisited and revised. [Circ Res. 2007] Gain and cardiac E-C coupling: revisited and revised.Wier WG. Circ Res. 2007 Sep 14; 101(6):533-5. Review Novel therapeutic approaches for heart failure by normalizing calcium cycling. [Nat Rev Drug Discov. 2004] Review Novel therapeutic approaches for heart failure by normalizing calcium cycling.Wehrens XH, Marks AR. Nat Rev Drug Discov. 2004 Jul; 3(7):565-73. CaM or cAMP: linking beta-adrenergic stimulation to ‘leaky’ RyRs. [Circ Res. 2007] CaM or cAMP: linking beta-adrenergic stimulation to ‘leaky’ RyRs.Sipido KR. Circ Res. 2007 Feb 16; 100(3):296-8. Review Molecular determinants of altered contractility in heart failure. [Ann Med. 2004] Review Molecular determinant