Can DNA Immunization Against CD28 or CTLA-4 Prevent Rheumatic Disease in Rodent Models?
According to an abstract submitted by the authors to the NATO Advanced Studies Institute Conference titled Targeting of Drugs: Strategies for Gene Constructs and Delivery, held June 24 – July 5, 1999, in Marathon, Greece, “Introduction of plasmid DNA encoding an antigenic protein into skeletal muscle by injection of purified DNA has been shown in a number of different systems to be capable of inducing antibody formation, CD4+ T-cell activation, and cytokine secretion, as well as the induction of cytotoxic T lymphocytes (CTL). The power of this technology lies not only with the low cost of production, stability, and ease of delivery of DNA-based vaccines, but also in the…
