Can gene therapy promote regeneration after distal axonal injury in the brain?
Using combinations of gene therapy and neural transplantation, Harvey and Rodger have successfully induced repair of the optic nerve when the nerve injury was close to the retinal ganglion cells (RGCs) in the eye. However it was important to know whether this approach enhances re-growth after an injury further along the length of the nerve tract, as is commonly the case with spinal cord injury. This project therefore looked at whether genetic manipulation and peripheral nerve grafting stimulates re-growth after an optic nerve injury occurring at a long distance from the eye’s RGCs. Encouraging results were obtained with this approach and overall, the pilot study has assisted in planning future experiments to progress this work. Dr S Hodgetts, Dr G Plant, Dr P Simmons (2009,2010) Grant Title: Neuronal regeneration & improved functional outcome after complete transection SCI in rats using combinatorial therapies. Many animal studies in spinal cord regeneration have used an incomplete ‘br
Related Questions
- What is the difference between an Attention-Deficit Disorder and an Attention-Deficit/Hyperactivity Disorder?
- I lost vision in my eye as a result of an injury or retinal detachment - might gene therapy restore my vision?
- Is Current Imaging Good Enough to Differentiate Radiation-Induced Brain Injury from Tumor Recurrence?
