Can I overdose or have systemic effects from using such high concentrations of minoxidil?
A. For essentially all patients, there is not sufficient absorption of minoxidil into the blood stream to cause systemic symptoms. In fact, allowing for the average amount of absorption (1.4%), the safety margin is almost ten-fold, using topical 12.5% minoxidil. However, there will be those few patients who will be hypersensitive to minoxidil or have an idiosyncratic reaction to Xandrox 12.5% Lotion®. That percentage of patients is less than 0.1%, and they should not use high concentration minoxidil compounds.
