Neurofeedback can begin whether or not you take medication. Many individuals seek neurofeedback because it is a medication-free alternative for reducing and eliminating disruptive symptoms. Individuals who do not respond well to medication may benefit from neurofeedback. Some individuals are helped with a combination of medication and neurofeedback. The basic difference between medication and neurofeedback is that medication treats the symptom, whereas neurofeedback treats the cause or the source of the symptom. Medication is chemical regulation, whereas neurofeedback is self-regulation. Neurofeedback trains the brain to regulate itself.