Can Wellbutrin cause weight gain?
• A: Wellbutrin (bupropion) immediate-release formulation may cause weight loss of about five pounds in 28 percent of patients. The sustained-release formulation may cause weight loss in about 15 percent of the patients. Up to 25 percent of patients on the XL formulation lost greater than five pounds. It is very unlikely Wellbutrin will cause weight gain. Weight gain is often noticed in patients whose depression is not controlled. Please see http://www.everydayhealth.com/drugs/wellbutrin/side-effects.