Can you take Stemetil with Clomipramine (Anafanil)?
Stemetil (prochlorperazine) and Anafranil (clomipramine) have a moderate drug-drug interaction You can take these 2 medicines together but with caution. Coadministration of a phenothiazine (Stemetil) with a tricyclic antidepressant (TCA – Anafranil) may result in elevated plasma concentrations of one or both drugs as well as additive adverse effects. Although these drugs have been used together clinically, the possibility of increased risk of serious adverse effects such as central nervous system depression, tardive dyskinesia, hypotension, and prolongation of the QT interval should be considered, as many of these agents alone can and have produced these effects. In addition, excessive anticholinergic effects may occur in combination use, which can result in hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of anticholinergic intoxication commonly include blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary
