Clinical and laboratory features of community-associated methicillin-resistant Staphylococcus aureus: is it really new?
OBJECTIVE: To review the epidemiologic and molecular characteristics of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Detroit, Michigan, to assess the risk factors for infection and the response to therapy. DESIGN: Prospective clinical and laboratory study of 2003-2004 CA-MRSA isolates. Molecular features were compared with CA-MRSA isolates from 1980. SETTING: A 600-bed urban academic medical center. PATIENTS: Twenty-three patients with CA-MRSA infections from 2003-2004 were evaluated. In addition, laboratory analysis was performed on 13 CA-MRSA isolates from 1980. MAIN OUTCOME MEASURES: Laboratory analysis of isolates included antimicrobial susceptibility testing, pulsed-field genotyping, testing for Panton-Valentine leukocidin (PVL) genes, and staphylococcal cassette chromosome mec typing. RESULTS: Patients were predominantly young African American males and presented with skin and soft-tissue infections. All isolates were resistant to erythromycin and
Related Questions
- Does ascertainment bias affect reports on the incidence of multidrug-resistant, community-associated methicillin-resistant Staphylococcus aureus infection?
- What proportion of hospital patients colonized with methicillin-resistant Staphylococcus aureus are identified by clinical microbiological cultures?
- Clinical and laboratory features of community-associated methicillin-resistant Staphylococcus aureus: is it really new?
