Dementia patients are older people, who often have impaired renal or hepatic function. Can I prescribe memantine in these cases, and what dosage should be used?
In patients with normal to mildly impaired renal function (serum creatinine levels of up to 130 µmol/l) no dose reduction is needed. In patients with moderate renal impairment (creatinine clearance 40 – 60 ml/min/1.73 m2) the dose should be reduced to 10 mg per day. No data are available for patients with severely reduced kidney function, and thus memantine is not recommended to be used in these patients.
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