It is not necessary to store Bene-Bac in the refrigerator. It is especially not recommended for either Bird or Pet Bene-Bac Powder as the moisture in your refrigerator may get into the jar, causing the powder to clump and harden. Bene-Bac needs to be kept in a cool, dry place where it will not be exposed to temperatures higher than 120 F. Temperatures higher than that may kill the beneficial bacteria in the product, promote growth of unwanted bacteria, and cause rancidity of the oil. When using Bird Bene-Bac in a hand-rearing formula, heat the formula first before adding the Bird Bene-Bac.