Do orphan G-protein-coupled receptors have ligand-independent functions?
New insights from receptor heterodimersAngélique Levoye1,2,3,4,*, Julie Dam1,2,3,4,*, Mohammed A Ayoub1,2,3,4,5, Jean-Luc Guillaume1,2,3,4 & Ralf Jockers1,2,3,4 Institut Cochin, Department of Cell Biology, UMR-S 8104, 22 rue Méchain, Paris F-75014, France Inserm, U567, UMR-S 8104, 22 rue Méchain, Paris F-75014, France CNRS, UMR 8104, UMR-S 8104, 22 rue Méchain, Paris F-75014, France Université Paris Descartes, Faculté de Médecine René Descartes, UMR-S 8104, 22 rue Méchain, Paris F-75014, France Present address: Institut de Génomique Fonctionnelle (IGF), UMR5203 CNRS, U661 INSERM, Universités Montpellier 1 & 2, Département de Pharmacologie Moléculaire, 141 rue de la Cardonille 34094, Montpellier Cedex 05, France Correspondence to: Ralf Jockers, Tel: +33 1 40 51 64 34; Fax: +33 1 40 51 64 30; E-mail: jockers@cochin.inserm.fr *These authors contributed equally to this workReceived 29 May 2006; Accepted 15 September 2006G-protein-coupled receptors (GPCRs) are important drug targets and are
