Does calorie restriction extend maximal lifespan in nonhuman primates?
Although it has been suggested that the slowing of aging by calorie restriction is a general phenomenon that applies to all species, there is currently no evidence that calorie restriction may extend maximal lifespan in nonhuman primates. There are two longevity studies (one at the University of Wisconsin, the other at the National Institute on Aging in USA), which are examining the long-term effects of calorie restriction on aging in rhesus monkeys. Up to now, the experimental data have shown that many of the metabolic, hormonal and structural adaptations that take place in calorie restriction rodents happen also in calorie restricted monkeys. Calorie restricted monkeys have approximately 70% lower body fat, higher insulin sensitivity, lower serum triiodothyronine concentration and core body temperature, and reduced inflammation, glycation and oxidative damage of several tissues [75,82–87]. They are protected against dyslipidemia and type 2 diabetes [88]. In addition, immune senescenc
