Does desmopressin improve hemostasis and reduce blood loss from aortic surgery?
Author(s): Clagett GP, Valentine RJ, Myers SI, Chervu A, Heller J Affiliation(s): Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235-9031, USA. Publication date & source: 1995-09, J Vasc Surg., 22(3):223-9 Publication type: Clinical Trial; Randomized Controlled Trial PURPOSE: The purpose of this study was to determine the effect of desmopressin acetate (DDAVP) on blood loss, transfusion requirements, and thromboembolic complications in patients undergoing elective aortic operations. METHODS: A randomized, double-blind trial was carried out during a 3-year period with patients receiving 20 micrograms DDAVP or identical-appearing placebo at the time of aortic cross-clamp placement. In addition to major bleeding and thromboembolic end points, bleeding times and platelet counts were monitored serially. RESULTS: Forty-three patients were randomized to receive DDAVP, and 48 were assigned to a placebo. An equivalent proportion of patients with aneurysm and pa
